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Name: 王柯敏 Kemin Wang Title: Principal Investigator, Ph D. Professor Email: kmwang@hnu.edu.cn Phone: +086-731-88821566

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研究方向:纳米及分子水平上的生物分析化学、分子工程、纳米生物医学器件、化学与生物传感器
Reserch Interest: Bioanalytical Chemistry on Nanometer and Molecule Level, Molecule Engineering, Nanobiomedical Devices, Chemical and Biological Sensors

    1957年生,1987年获湖南大学分析化学博士学位,1989-1991年在瑞士苏黎世联邦高等理工学院(ETH)进行博士后研究。1992年晋升为湖南大学教授。他是国家杰出青年基金获得者(1998)、国家自然科学基金委化学科学部专家咨询委员会委员(2008至今)、专家评审组成员(2010年至今)、《The Analyst》顾问编委、《高等学校化学学报》副主编、《中国化学快报》副主编,以第一完成人获2011年国家自然科学二等奖、2009年湖南省自然科学一等奖、2003年湖南省科技进步一等奖等多项奖励。

He was born in 1957, obtained Ph.D. from Hunan University in 1987, and undertook post-doctoral studies at the ETH Zurich in Switzerland from 1989 to 1991. He has been a professor at Hunan University since 1992. He is the gainer of National Outstanding Youth Foundation of China (1998), the member of Expert Advisory Committee (2008-) and Panel Review Committees (2010-) of Department of Chemical Science in National Natural Science Foundation of China, the member of Advisory Board of The Analyst, the Vice Editor-in-chief of Chemical Journal of Chinese University, the Associate Editors-in-Chief of Chinese Chemical Letters. As the first-ranked, he earned the National Natural Science Award (2nd Class, 2011), the Natural Science Award of Hunan Province (1st Class, 2009), and the Science and Technology Progress Award of Hunan Province (1st Class, 2003), etc. 

Selected Publications

    1. Wang KM*, He XX, Yang XH, Shi H. Functionalized Silica Nanoparticles: A Platform for Fluorescence Imaging at the Cell and Small Animal Levels, Acc. Chem. Res. 2013, 46, 1367-1376.

    2. Qing ZH, He XX, He DG, Wang KM*, Xu FZ, Qing TP, Yang X. Poly(thymine)-Templated Selective Formation of Fluorescent Copper Nanoparticles, Angew. Chem. Int. Ed. 2013, 52, 9719-9722.

    3. Huang J, Yang XH, He XX, Wang KM*, He Y, Quan K. A New Strategy for Designing a Graphene Oxide-based DNA Hairpin Probe: Fluorescence Upon Switching the Orientation of the Sticky End, Chem.Commun. 2013, 49, 9827-9829.

    4.Liu P, Yang XH, Sun S, Wang Q, Wang KM*, Huang J, Liu JB, He LL. Enzyme-Free Colorimetric Detection of DNA by Using Gold Nanoparticles and Hybridization Chain Reaction Amplification, Anal. Chem. 2013, 85, 7689-7695.

    5. Wang Q, Yang LJ, Yang XH, Wang KM*, He LL, Zhu JQ, Su TY. An Electrochemical DNA Biosensor Based on the ‘‘Y’’ Junction Structure and Restriction Endonuclease-aided Target Recycling Strategy, Chem. Commun. 2012, 48, 2982-2984.

    6. He XX, Wang YS, Wang KM*, Chen M, Chen SY. Fluorescence Resonance Energy Transfer Mediated Large Stokes Shifting Near-Infrared Fluorescent Silica Nanoparticles for in Vivo Small-Animal Imaging, Anal. Chem. 2012, 84, 9056-9064. 

    7. Liu JB, Yang XH, Wang KM*, He XX, Wang Q, Huang J, Liu Y. Aggregation Control of Quantum Dots through Ion-Mediated Hydrogen Bonding Shielding, ACS Nano 2012, 6, 4973-4983.

    8. He DG, He XX, Wang KM*, Cao J, Zhao YX. A Photon-Fueled Gate-Like Delivery System Using i-Motif DNA Functionalized Mesoporous Silica Nanoparticles, Adv. Funct. Mater. 2012, 22, 4704-4710.

    9. Shi H, He XX, Wang KM*, Wu X, Ye XS, Guo QP, Tan WH, Qing ZH, Yang XH, Zhou B. Activatable Aptamer Probe for Contrast-enhanced in vivo Cancer Imaging Based on Cell Membrane Protein-triggered Conformation Alteration, Proc. Natl. Acad. Sci. USA 2011, 108, 3900-3905. 

    10. Huang J, Wu YR, Chen Y, Zhu Z, Yang XH, Yang CY*, Wang KM*, Tan WH*. Pyrene-Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids, Angew. Chem. Int. Ed. 2011, 50, 401-404.

    11. Liu JB, Yang XH, Wang KM*, Yang RH, Ji HN, Yang LY, Wu CL. A Switchable Fluorescent Quantum Dot Probe Based on Aggregation/disaggregation Mechanism, Chem. Commun. 2011, 47, 935-937.

    12. Tang ZW, Liu P, Ma CB, Yang XH, Wang KM*, Tan WH, Lv XY. Molecular Beacon Based Bioassay for Highly Sensitive and Selective Detection of Nicotinamide Adenine Dinucleotide and the Activity of Alanine Aminotransferase, Anal. Chem. 2011, 83, 2505-2510.

    13. Shi H, He XX, Yuan Y, Wang KM*, Liu D. Nanoparticle-Based Biocompatible and Long-Life Marker for Lysosome Labeling and Tracking, Anal. Chem. 2010, 82, 2213-2220.

    14.Huang J, Zhu Z, Bamrungsap S, Zhu GZ, You MX, He XX, Wang KM*, Tan WH*. Competition-Mediated Pyrene-Switching Aptasensor: Probing Lysozyme in Human Serum with a Monomer-Excimer Fluorescence Switch, Anal. Chem. 2010, 82, 10158-10163.

    15. Wang KM*, Tang ZW, Yang CY, Kim YM, Fang XH, Li W, Wu YR, Medley CD, Cao ZH, Li J, Colon P, Lin H, Tan WH*. Molecular Engineering of DNA: Molecular Beacons, Angew. Chem. Int. Ed. 2009, 48, 856-870. 

    16. Liu JB, Yang XH, Wang KM*, Wang D, Zhang PF. Chemical Etching with Tetrafluoroborate: a Facile Method for Resizing of CdTe Nanocrystals Under Mild Conditions, Chem. Commun. 2009, 6080-6082. 

    17. Guo QP, Yang XH, Wang KM*, Tan WH, Li W, Tang HX, Li HM. Sensitive Fluorescence Detection of Nucleic Acids Based on Isothermal Circular Strand-displacement Polymerization Reaction, Nucleic Acids Res. 2009, 37, e20.